Response of HL-A identical unrelated individuals in the mixed lymphocyte culture test.
نویسندگان
چکیده
The immunological responsiveness as measured in the mixed lymphocyte culture test has been studied in 13 pairs of HL-A identical unrelated individuals. In all combinations stimulation occurred and it was frequently of a similar magnitude to that observed against non-HL-A identical subjects.It is postulated that another locus, adjacent to the HL-A locus, is also responsible for the non-stimulation observed between HL-A identical siblings, and that observations made in the related situation should not be transposed to the unrelated situation without some reservation.
منابع مشابه
Two separate genes controlling stimulation in mixed lymphocyte reaction in man.
The genetic control of strong stimulation in the mixed lymphocyte culture reaction is determined by a separate gene (MLR-S) closely linked to the FOUR-locus of the HL-A chromosomal region. Three additional examples of siblings with recombination between FOUR-locus and MLR-S locus are presented which confirms the independent genetic control of mixed lymphocyte reaction from the control of HL-A a...
متن کاملDiminished mixed lymphocyte reaction in ankylosing spondylitis, relatives, and normal individuals all with HL-A 27.
The mixed lymphocyte reaction against a pool of blocked lymphocytes was studied in individuals with and without HL-A 27, including controls, spouses, parents, sibs, and offspring, and patients with ankylosing spondylitis. In controls without HL-A 27 the mean increment of counts perminute was 46,630 compared with 29,860 in asymptomatic controls and relatives with HL-A 27 and 26,277 in spondyliti...
متن کاملAplastic anemia: failure of patient leukocytes to stimulate allogeneic cells in mixed leukocyte culture.
One-way mixed leukocyte cultures were used to study the ability of cells from 53 patients with aplastic anemia and 65 of their HLA-identical siblings to stimulate and to respond to cells from unrelated individuals. The capacity of leukocytes from 28 of 53 patients to stimulate was diminished or absent, wheras their ability to respond remained comparable to that of cells from their HLA-identical...
متن کاملThird party mixed-leukocyte culture test: a potential new method of histocompatibility testing.
The disparity index is an expression of histocompatibility difference between two siblings with identical human leukocyte antigen (HL-A) type who are nonreactive in mixed leukocyte culture (MLC) test. This index is derived from a third-party MLC test. The disparity index was found to be correlated with the severity of graft-versus-host reaction in bone marrow transplantation between HL-A-identi...
متن کاملSHORT COMMUNICATION Mixed Lymphocyte Culture Reactivity and H-2 Histocompatibility Loci Diff erencesl”
The relationship between the major histocompatibility systems as defined serologically and by the mixed leukocyte culture (MLC) test is one which has received attention in both man (1) and mouse (2). In man, studies within families suggest that cells of siblings who inherit the same HL-A chromosomes from their parents and thus are serologically identical at HL-A do not stimulate in the MLC test...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- British medical journal
دوره 4 5787 شماره
صفحات -
تاریخ انتشار 1971